Do you have a technical question that doesn't really fit a specific console? Want some general info on electronics, hacking, making cookies, etc? Here's the place to ask! Go nuts.
You could pull up the edge of the screen protector with a knife and take a bottle of compressed air, slip the nozzle straw-thing into the corner then just blow all the dust into the opposite corner where it won't be seen.
Prying it open shouldn't hurt anything, unless you violently stab your system . Opening it is the only way to clean out the dust. To keep out dust the only way would be to seal all the cracks and seems which would hurt the system.